Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A353delFs

c.1057_1058delGC

Surrounding Variants

3 papers

NM_000546.6

p.A353A

c.1059C>G

1 paper

NM_000546.6

p.A353A

c.1059C>A

1 paper

NM_000546.6

p.D352_A353delFs

c.1054_1058del5

1 paper

NM_000546.6

p.F341_A353delFs

c.1022_1058del37

1 paper

NM_000546.6

p.Q354fs

c.1060_1061fs

10 papers

NM_000546.6

p.Q354*

c.1060C>T

5 papers

NM_000546.6

p.A353V

c.1058C>T

7 papers

NM_000546.6

p.Q354E

c.1060C>G

2 papers

NM_000546.6

p.A353G

c.1058C>G

2 papers

NM_000546.6

p.Q354_A355insCA

c.1060_1064ins6

21 papers

NM_000546.6

p.Q354K

c.1060C>A

4 papers

NM_000546.6

p.A353D

c.1058C>A