Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.A353P

c.1057G>C

Surrounding Variants

6 papers

NM_000546.6

p.A353S

c.1057G>T

11 papers

NM_000546.6

p.A353T

c.1057G>A

1 paper

NM_000546.6

p.D352fs

c.1054_1055fs

1 paper

NM_000546.6

p.D352insFs

c.1055dupA

2 papers

NM_000546.6

p.D352E

c.1056T>G

2 papers

NM_000546.6

p.D352E

c.1056T>A

1 paper

NM_000546.6

p.A347_D352delFs

c.1039_1055del17

2 papers

NM_000546.6

p.E336_K351del16

c.1006_1052del48

5 papers

NM_000546.6

p.A353V

c.1058C>T

2 papers

NM_000546.6

p.A353G

c.1058C>G

4 papers

NM_000546.6

p.A353D

c.1058C>A

3 papers

NM_000546.6

p.A353A

c.1059C>G