Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D352insFs

c.1055dupA

Surrounding Variants

1 paper

NM_000546.6

p.D352fs

c.1054_1055fs

2 papers

NM_000546.6

p.D352E

c.1056T>G

2 papers

NM_000546.6

p.D352E

c.1056T>A

1 paper

NM_000546.6

p.A347_D352delFs

c.1039_1055del17

2 papers

NM_000546.6

p.E336_K351del16

c.1006_1052del48

6 papers

NM_000546.6

p.A353S

c.1057G>T

6 papers

NM_000546.6

p.A353P

c.1057G>C

11 papers

NM_000546.6

p.A353T

c.1057G>A

6 papers

NM_000546.6

p.D352V

c.1055A>T

12 papers

NM_000546.6

p.D352G

c.1055A>G

NM_001126115.2

p.D220G

c.659A>G

6 papers

NM_000546.6

p.D352A

c.1055A>C

2 papers

NM_000546.6

p.D352delFs

c.1054delC