Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.K351fs

c.1051_1052fs

Surrounding Variants

25 papers

NM_000546.6

p.K351N

c.1053G>T

26 papers

NM_000546.6

p.K351N

c.1053G>C

NM_001126118.2

p.K312N

c.936G>C

1 paper

NM_000546.6

p.K351K

c.1053G>A

3 papers

NM_000546.6

p.K351delFs

c.1052delT

1 paper

NM_000546.6

p.R335_K351del0

c.1005_1052del48

2 papers

NM_000546.6

p.D352fs

c.1054_1055fs

12 papers

NM_000546.6

p.D352Y

c.1054G>T

8 papers

NM_000546.6

p.D352H

c.1054G>C

17 papers

NM_000546.6

p.D352N

c.1054G>A

2 papers

NM_000546.6

p.K351_D352delins

c.1053_1054delinsCT

1 paper

NM_000546.6

p.K351_D352delins

c.1053_1054delinsAA

1 paper

NM_000546.6

p.N345_K351delFs

c.1034_1053del20