Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L350L

c.1050C>T

Surrounding Variants

3 papers

NM_000546.6

p.L350_K351insFs

c.1050_1051insT

1 paper

NM_000546.6

p.L350fs

c.1048_1049fs

1 paper

NM_000546.6

p.L350delFs

c.1049delA

1 paper

NM_000546.6

p.E346_L350delFs

c.1036_1049del14

1 paper

NM_000546.6

p.L350insFs

c.1048dupC

4 papers

NM_000546.6

p.L350R

c.1049T>G

13 papers

NM_000546.6

p.L350P

c.1049T>C

3 papers

NM_000546.6

p.L350H

c.1049T>A

3 papers

NM_000546.6

p.K351fs

c.1051_1052fs

24 papers

NM_000546.6

p.K351*

c.1051A>T

24 papers

NM_000546.6

p.K351E

c.1051A>G

5 papers

NM_000546.6

p.K351Q

c.1051A>C