Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.E346D

c.1038G>T

Surrounding Variants

2 papers

NM_000546.6

p.E346fs

c.1036_1037fs

1 paper

NM_000546.6

p.N345_E346insFs

c.1034_1037dup4

6 papers

NM_000546.6

p.E346D

c.1038G>C

6 papers

NM_000546.6

p.E346E

c.1038G>A

1 paper

NM_000546.6

p.E346delFs

c.1037delT

1 paper

NM_000546.6

p.N345_E346delFs

c.1034_1037del4

8 papers

NM_000546.6

p.A347S

c.1039G>T

1 paper

NM_000546.6

p.E343_E346insFs

c.1028_1038dup11

14 papers

NM_000546.6

p.A347P

c.1039G>C

43 papers

NM_000546.6

p.A347T

c.1039G>A

NM_001276697.3

p.A188T

c.562G>A

2 papers

NM_000546.6

p.E346delFs

c.1037_1038delCT

1 paper

NM_000546.6

p.R342_E346del5

c.1024_1037del15