Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.E346Q

c.1036G>C

Surrounding Variants

41 papers

NM_000546.6

p.E346*

c.1036G>T

5 papers

NM_000546.6

p.N345insFs

c.1035dupT

1 paper

NM_000546.6

p.E346insFs

c.1036_1037ins13

1 paper

NM_000546.6

p.E346_A347ins7

c.1036_1040ins21

21 papers

NM_000546.6

p.E346K

c.1036G>A

1 paper

NM_000546.6

p.N345del1

c.1033_1034delATT

1 paper

NM_000546.6

p.R342_N345del4

c.1024_1034del12

5 papers

NM_000546.6

p.E346fs

c.1036_1037fs

1 paper

NM_000546.6

p.N345_E346insFs

c.1035_1036insCT

6 papers

NM_000546.6

p.N345fs

c.1033_1034fs

36 papers

NM_000546.6

p.N345K

c.1035T>G

38 papers

NM_000546.6

p.N345K

c.1035T>A