Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

125 papers

NM_000546.6

p.L344P

c.1031T>C

Surrounding Variants

49 papers

NM_000546.6

p.L344R

c.1031T>G

9 papers

NM_000546.6

p.L344Q

c.1031T>A

1 paper

NM_000546.6

p.L344delFs

c.1030delG

1 paper

NM_000546.6

p.E343_L344delFs

c.1027_1030del4

1 paper

NM_000546.6

p.L344insFs

c.1031dupT

1 paper

NM_000546.6

p.L344_N345insFs

c.1032_1033insAT

5 papers

NM_000546.6

p.L344fs

c.1030_1031fs

2 papers

NM_000546.6

p.L344L

c.1032G>C

2 papers

NM_000546.6

p.L344L

c.1032G>A

1 paper

NM_000546.6

p.L344delFs

c.1031delA

1 paper

NM_000546.6

p.L344fs

c.1030_1031fs

1 paper

NM_000546.6

p.R342_L344delFs

c.1024_1031del8