Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L344fs

c.1030_1031fs

Surrounding Variants

2 papers

NM_000546.6

p.L344L

c.1030C>T

2 papers

NM_000546.6

p.L344V

c.1030C>G

5 papers

NM_000546.6

p.L344M

c.1030C>A

1 paper

NM_000546.6

p.E343delFs

c.1029delC

4 papers

NM_000546.6

p.E343delFs

c.1028_1029delCT

1 paper

NM_000546.6

p.M340_E343del4

c.1018_1028del12

1 paper

NM_000546.6

p.E339_E343delFs

c.1016_1029del14

1 paper

NM_000546.6

p.E336_E343delFs

c.1008_1029del22

49 papers

NM_000546.6

p.L344R

c.1031T>G

125 papers

NM_000546.6

p.L344P

c.1031T>C

9 papers

NM_000546.6

p.L344Q

c.1031T>A

1 paper

NM_000546.6

p.L344delFs

c.1030delG