Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.E343G

c.1028A>G

Surrounding Variants

5 papers

NM_000546.6

p.E343V

c.1028A>T

12 papers

NM_000546.6

p.E343A

c.1028A>C

1 paper

NM_000546.6

p.R337_E343insFs

c.1009_1027dup19

1 paper

NM_000546.6

p.E343delFs

c.1027delC

1 paper

NM_000546.6

p.R342_E343del1

c.1025_1027delCTC

1 paper

NM_000546.6

p.R342_E343delFs

c.1024_1027del4

1 paper

NM_000546.6

p.R337_E343delFs

c.1009_1027del19

2 papers

NM_000546.6

p.G334_R342del9

c.1000_1025del27

57 papers

NM_000546.6

p.E343*

c.1027G>T

6 papers

NM_000546.6

p.E343D

c.1029G>T

13 papers

NM_000546.6

p.E343fs

c.1027_1028fs

11 papers

NM_000546.6

p.E343Q

c.1027G>C