Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.R342G

c.1024C>G

Surrounding Variants

618 papers

NM_000546.6

p.R342*

c.1024C>T

NM_001126115.2

p.R210*

c.628C>T

1 paper

NM_000546.6

p.R342insFs

c.1024_1025insAC

1 paper

NM_000546.6

p.R342_E343insG

c.1024_1028ins3

1 paper

NM_000546.6

p.R342_E343ins13

c.1024_1028ins39

2 papers

NM_000546.6

p.R342R

c.1024C>A

2 papers

NM_000546.6

p.F341_R342delins

c.1023_1024delinsTT

1 paper

NM_000546.6

p.F341_R342delins

c.1023_1024delinsAT

8 papers

NM_000546.6

p.E339_F341del3

c.1015_1022del9

37 papers

NM_000546.6

p.R342fs

c.1024_1025fs

6 papers

NM_000546.6

p.R342L

c.1025G>T

140 papers

NM_000546.6

p.R342P

c.1025G>C

35 papers

NM_000546.6

p.R342Q

c.1025G>A