Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.F338delFs

c.1014delG

Surrounding Variants

101 papers

NM_000546.6

p.E339*

c.1015G>T

1 paper

NM_000546.6

p.F338insFs

c.1014dupC

1 paper

NM_000546.6

p.E339ins6

c.1015_1016ins18

20 papers

NM_000546.6

p.E339Q

c.1015G>C

50 papers

NM_000546.6

p.E339K

c.1015G>A

NM_001126115.2

p.E207K

c.619G>A

11 papers

NM_000546.6

p.E339fs

c.1015_1016fs

12 papers

NM_000546.6

p.F338F

c.1014C>T

23 papers

NM_000546.6

p.F338L

c.1014C>G

4 papers

NM_000546.6

p.F338insFs

c.1013_1014insT

8 papers

NM_000546.6

p.F338fs

c.1012_1013fs

1 paper

NM_000546.6

p.F338_E339ins1

c.1014_1015ins3

22 papers

NM_000546.6

p.F338L

c.1014C>A