Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.F338F

c.1014C>T

Surrounding Variants

23 papers

NM_000546.6

p.F338L

c.1014C>G

4 papers

NM_000546.6

p.F338insFs

c.1013_1014insT

8 papers

NM_000546.6

p.F338fs

c.1012_1013fs

1 paper

NM_000546.6

p.F338_E339ins1

c.1014_1015ins3

22 papers

NM_000546.6

p.F338L

c.1014C>A

5 papers

NM_000546.6

p.F338delFs

c.1013delA

1 paper

NM_000546.6

p.F338insFs

c.1013_1014ins5

7 papers

NM_000546.6

p.F338C

c.1013T>G

12 papers

NM_000546.6

p.F338S

c.1013T>C

3 papers

NM_000546.6

p.F338Y

c.1013T>A

1 paper

NM_000546.6

p.E336_F338delFs

c.1008_1012del5

1 paper

NM_000546.6

p.G334_F338delFs

c.1002_1012del11