Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.F338S

c.1013T>C

Surrounding Variants

1 paper

NM_000546.6

p.F338insFs

c.1013_1014ins5

7 papers

NM_000546.6

p.F338C

c.1013T>G

3 papers

NM_000546.6

p.F338Y

c.1013T>A

1 paper

NM_000546.6

p.E336_F338delFs

c.1008_1012del5

1 paper

NM_000546.6

p.G334_F338delFs

c.1002_1012del11

1 paper

NM_000546.6

p.R337insFs

c.1010_1011dupGC

1 paper

NM_000546.6

p.F338_E339insT

c.1012_1016ins3

4 papers

NM_000546.6

p.F338V

c.1012T>G

23 papers

NM_000546.6

p.F338L

c.1012T>C

18 papers

NM_000546.6

p.F338I

c.1012T>A

2 papers

NM_000546.6

p.R337delFs

c.1010_1011delGC

1 paper

NM_000546.6

p.R337del1

c.1009_1010delGCG