Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

599 papers

NM_000546.6

p.R337H

c.1010G>A

Surrounding Variants

157 papers

NM_000546.6

p.R337L

c.1010G>T

2 papers

NM_000546.6

p.R337insFs

c.1010_1011insA

48 papers

NM_000546.6

p.R337P

c.1010G>C

1 paper

NM_000546.6

p.R335_R337delFs

c.1003_1009del7

386 papers

NM_000546.6

p.R337C

c.1009C>T

NM_001126118.2

p.R298C

c.892C>T

2 papers

NM_000546.6

p.R337R

c.1011C>T

23 papers

NM_000546.6

p.R337G

c.1009C>G

2 papers

NM_000546.6

p.R337R

c.1011C>G

1 paper

NM_000546.6

p.R337_F338insFs

c.1011_1012insT

1 paper

NM_000546.6

p.G334_E336insFs

c.1001_1008dup8

7 papers

NM_000546.6

p.R337fs

c.1009_1010fs

1 paper

NM_000546.6

p.R337_F338insGTC

c.1009_1013ins9