Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R335_E336Fs

c.1004_1006delinsTFs

Surrounding Variants

109 papers

NM_000546.6

p.E336*

c.1006G>T

NM_001126115.2

p.E204*

c.610G>T

2 papers

NM_000546.6

p.R335insFs

c.1005dupT

3 papers

NM_000546.6

p.E336Q

c.1006G>C

7 papers

NM_000546.6

p.E336K

c.1006G>A

1 paper

NM_000546.6

p.R335_E336delins

c.1005_1006delinsAT

1 paper

NM_000546.6

p.R335delFs

c.1005delA

14 papers

NM_000546.6

p.E336fs

c.1006_1007fs

10 papers

NM_000546.6

p.R335fs

c.1003_1004fs

1 paper

NM_000546.6

p.R335R

c.1005T>G

1 paper

NM_000546.6

p.R335R

c.1005T>C

1 paper

NM_000546.6

p.R335R

c.1005T>A

4 papers

NM_000546.6

p.R335delFs

c.1004delC