Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

24 papers

NM_000546.6

p.R335C

c.1003C>T

Surrounding Variants

13 papers

NM_000546.6

p.R335fs

c.1003_1004fs

7 papers

NM_000546.6

p.R335G

c.1003C>G

1 paper

NM_000546.6

p.R333_G334insFs

c.998_1001dup4

1 paper

NM_000546.6

p.R335insFs

c.1003_1004insA

1 paper

NM_000546.6

p.R335S

c.1003C>A

1 paper

NM_000546.6

p.R335Fs

c.1003delinsGAFs

2 papers

NM_000546.6

p.G334delFs

c.1002delC

8 papers

NM_000546.6

p.R335L

c.1004G>T

6 papers

NM_000546.6

p.G334fs

c.1000_1001fs

1 paper

NM_000546.6

p.R335insFs

c.1004_1005ins1

1 paper

NM_000546.6

p.R335insFs

c.1004_1005insA

3 papers

NM_000546.6

p.R335P

c.1004G>C