Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

51 papers

NM_000546.6

p.G334R

c.1000G>A

Surrounding Variants

47 papers

NM_000546.6

p.G334W

c.1000G>T

2 papers

NM_000546.6

p.R333insFs

c.999dupT

1 paper

NM_000546.6

p.G334insFs

c.1000_1001insTG

51 papers

NM_000546.6

p.G334R

c.1000G>C

1 paper

NM_000546.6

p.I332_R333del2

c.994_998del6

1 paper

NM_000546.6

p.G334fs

c.1000_1001fs

35 papers

NM_000546.6

p.R333fs

c.997_998fs

1 paper

NM_000546.6

p.R333R

c.999T>G

3 papers

NM_000546.6

p.R333delFs

c.998delC

1 paper

NM_000546.6

p.R333Fs

c.997_999delinsAGTGGGCGTGAFs

82 papers

NM_000546.6

p.G334V

c.1001G>T

9 papers

NM_000546.6

p.G334A

c.1001G>C