Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I332del1

c.994_995delGAT

Surrounding Variants

22 papers

NM_000546.6

p.R333fs

c.997_998fs

39 papers

NM_000546.6

p.R333C

c.997C>T

9 papers

NM_000546.6

p.R333G

c.997C>G

3 papers

NM_000546.6

p.R333S

c.997C>A

1 paper

NM_000546.6

p.R333L

c.998G>T

1 paper

NM_000546.6

p.R333insFs

c.998_999insT

1 paper

NM_000546.6

p.R333insFs

c.998_999ins5

3 papers

NM_000546.6

p.R333insFs

c.997dupC

9 papers

NM_000546.6

p.R333P

c.998G>C

28 papers

NM_000546.6

p.R333H

c.998G>A

NM_001276697.3

p.R174H

c.521G>A

31 papers

NM_000546.6

p.R333delFs

c.997delG

1 paper

NM_000546.6

p.I332_R333delFs

c.994_997del4