Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+311T>C

NM_001126113.3

p.S346P

c.1036T>C

Surrounding Variants

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+311T>G

NM_001126113.3

p.S346A

c.1036T>G

2 papers

NM_000546.6

p.Q331_I332Splc

c.993+310G>T

NM_001126113.3

p.S345S

c.1035G>T

4 papers

NM_000546.6

p.Q331_I332Splc

c.993+310G>A

NM_001126113.3

p.S345S

c.1035G>A

4 papers

NM_001126113.3

p.S346L

c.1037C>T

NM_000546.6

p.Q331_I332Splc

c.993+312C>T

2 papers

NM_001126113.3

p.S346W

c.1037C>G

NM_000546.6

p.Q331_I332Splc

c.993+312C>G

NM_001276760.3

p.Q292_I293Splc

c.876+312C>G

4 papers

NM_000546.6

p.Q331_I332Splc

c.993+313G>A

NM_001126113.3

p.S346S

c.1038G>A

3 papers

NM_000546.6

p.Q331_I332Splc

c.993+309C>T

NM_001126113.3

p.S345L

c.1034C>T

2 papers

NM_001126113.3

p.*347Q

c.1039T>C

NM_000546.6

p.Q331_I332Splc

c.993+314T>C

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+314T>A

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+307C>T

NM_001126113.3

p.N344N

c.1032C>T

4 papers

NM_000546.6

p.Q331_I332Splc

c.993+307C>G

NM_001126113.3

p.N344K

c.1032C>G

1 paper

NM_001126113.3

p.N344K

c.1032C>A