Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001126113.3

p.Y340Y

c.1020C>T

NM_000546.6

p.Q331_I332Splc

c.993+295C>T

Surrounding Variants

1 paper

NM_001126113.3

p.F341V

c.1021T>G

1 paper

NM_001126113.3

p.F341I

c.1021T>A

2 papers

NM_001126113.3

p.C339S

c.1016G>C

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+291G>A

2 papers

NM_000546.6

p.Q331_I332Splc

c.993+299C>T

NM_001126113.3

p.L342L

c.1024C>T

4 papers

NM_000546.6

p.Q331_I332Splc

c.993+290T>C

NM_001126113.3

p.C339R

c.1015T>C

2 papers

NM_001126113.3

p.C339S

c.1015T>A

NM_000546.6

p.Q331_I332Splc

c.993+290T>A

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+289G>A

4 papers

NM_001126113.3

p.W338R

c.1012T>C

NM_000546.6

p.Q331_I332Splc

c.993+287T>C

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+303T>A

1 paper

NM_001126113.3

p.W338R

c.1012T>A

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+286A>G