Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001126113.3

p.L333L

c.997C>T

Surrounding Variants

1 paper

NM_001126113.3

p.L333V

c.997C>G

3 papers

NM_000546.6

p.Q331_I332Splc

c.993+274A>G

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+277T>A

2 papers

NM_001126113.3

p.Q331_M332Splc

c.994-2A>G

NM_000546.6

p.Q331_I332Splc

c.993+267A>G

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+281T>G

NM_001126113.3

p.L336V

c.1006T>G

1 paper

NM_001126113.3

p.L336fs

c.1006_1007fs

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+282T>C

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+262G>A

1 paper

NM_001126113.3

p.L336F

c.1008A>T

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+283A>C

NM_001126113.3

p.L336F

c.1008A>C

4 papers

NM_001126113.3

p.R337*

c.1009C>T

NM_000546.6

p.Q331_I332Splc

c.993+284C>T

1 paper

NM_001126113.3

p.R337P

c.1010G>C

NM_000546.6

p.Q331_I332Splc

c.993+285G>C