Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001126114.3

p.F336V

c.1006T>G

Surrounding Variants

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+208T>A

1 paper

NM_001126114.3

p.Q337*

c.1009C>T

1 paper

NM_001126116.2

p.T202T

c.606C>T

1 paper

NM_001126116.2

p.Q205R

c.614A>G

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+203C>T

3 papers

NM_000546.6

p.Q331_I332Splc

c.993+213A>G

1 paper

NM_001126114.3

p.K338N

c.1014A>T

3 papers

NM_000546.6

p.Q331_I332Splc

c.993+216A>C

NM_001126114.3

p.K338N

c.1014A>C

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+217G>C

NM_001126114.3

p.E339Q

c.1015G>C

3 papers

NM_001126114.3

p.E339K

c.1015G>A

1 paper

NM_001126114.3

p.Q333*

c.997C>T

4 papers

NM_000546.6

p.Q331_I332Splc

c.993+199C>G

NM_001126114.3

p.Q333E

c.997C>G