Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+177C>T

Surrounding Variants

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+176C>T

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+184T>C

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+185A>G

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+189T>C

2 papers

NM_000546.6

p.Q331_I332Splc

c.993+189T>A

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+194A>G

NM_001126114.3

p.Q331_D332Splc

c.994-2A>G

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+195G>A

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+197A>G

5 papers

NM_001126114.3

p.D332D

c.996C>T

NM_000546.6

p.Q331_I332Splc

c.993+198C>T

1 paper

NM_001126114.3

p.Q333*

c.997C>T

4 papers

NM_000546.6

p.Q331_I332Splc

c.993+199C>G

NM_001126114.3

p.Q333E

c.997C>G

1 paper

NM_000546.6

p.Q331_I332Splc

c.993+203C>T