Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.L330_Q331insFs

c.990_991insT

Surrounding Variants

14 papers

NM_000546.6

p.Q331fs

c.991_992fs

225 papers

NM_000546.6

p.Q331*

c.991C>T

4 papers

NM_000546.6

p.Q331E

c.991C>G

3 papers

NM_000546.6

p.Q331_I332insAG

c.991_995ins6

7 papers

NM_000546.6

p.Q331K

c.991C>A

6 papers

NM_000546.6

p.L330delFs

c.990delA

1 paper

NM_000546.6

p.F328_L330delFs

c.983_990del8

18 papers

NM_000546.6

p.L330fs

c.988_989fs

1 paper

NM_000546.6

p.T329_L330delFs

c.985_989del5

1 paper

NM_000546.6

p.Y327_L330delFs

c.980_989del10

5 papers

NM_000546.6

p.Q331L

c.992A>T

33 papers

NM_000546.6

p.Q331R

c.992A>G