Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.L330V

c.988C>G

Surrounding Variants

8 papers

NM_000546.6

p.L330fs

c.988_989fs

15 papers

NM_000546.6

p.L330F

c.988C>T

5 papers

NM_000546.6

p.L330I

c.988C>A

1 paper

NM_000546.6

p.T329del1

c.985_986delGGT

2 papers

NM_000546.6

p.E326_T329del4

c.976_986del12

1 paper

NM_000546.6

p.D324_T329del6

c.970_986del18

1 paper

NM_000546.6

p.K321_T329del9

c.961_986del27

1 paper

NM_000546.6

p.L330insFs

c.988dupC

38 papers

NM_000546.6

p.L330R

c.989T>G

33 papers

NM_000546.6

p.L330P

c.989T>C

32 papers

NM_000546.6

p.L330H

c.989T>A

18 papers

NM_001126118.2

p.T290delFs

c.869delG

NM_000546.6

p.L330delFs

c.988delG