Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.F328L

c.982T>C

Surrounding Variants

1 paper

NM_000546.6

p.F328_T329ins7

c.982_986ins21

1 paper

NM_000546.6

p.F328insFs

c.982_983insA

11 papers

NM_000546.6

p.F328V

c.982T>G

2 papers

NM_000546.6

p.F328I

c.982T>A

1 paper

NM_000546.6

p.Y327delFs

c.980_981delAT

1 paper

NM_000546.6

p.L323_Y327del5

c.967_980del15

3 papers

NM_000546.6

p.P322_Y327del6

c.964_980del18

1 paper

NM_000546.6

p.K320_Y327del8

c.958_980del24

1 paper

NM_000546.6

p.Q317_Y327del11

c.949_980del33

13 papers

NM_000546.6

p.F328fs

c.982_983fs

10 papers

NM_000546.6

p.Y327fs

c.979_980fs

1 paper

NM_000546.6

p.Y327insFs

c.980dupA