Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P318_K319insT

c.952_956ins3

Surrounding Variants

3 papers

NM_000546.6

p.P318S

c.952C>T

1 paper

NM_000546.6

p.P318insFs

c.952_953insG

1 paper

NM_000546.6

p.P318insFs

c.952_953insA

2 papers

NM_000546.6

p.P318T

c.952C>A

3 papers

NM_000546.6

p.S313_Q317del5

c.937_950del15

1 paper

NM_000546.6

p.N311_Q317del7

c.931_950del21

7 papers

NM_000546.6

p.P318fs

c.952_953fs

8 papers

NM_000546.6

p.Q317H

c.951G>T

20 papers

NM_000546.6

p.Q317fs

c.949_950fs

1 paper

NM_000546.6

p.Q317_P318insFs

c.951_952insA

9 papers

NM_000546.6

p.Q317H

c.951G>C

1 paper

NM_000546.6

p.Q317Q

c.951G>A