Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P316R

c.947C>G

Surrounding Variants

16 papers

NM_000546.6

p.P316L

c.947C>T

1 paper

NM_000546.6

p.S315_P316insFs

c.945_946dupTC

2 papers

NM_000546.6

p.P316H

c.947C>A

6 papers

NM_000546.6

p.S315_P316delFs

c.945_946delGA

1 paper

NM_000546.6

p.S314_S315delFs

c.942_945del4

4 papers

NM_000546.6

p.P316S

c.946C>T

2 papers

NM_000546.6

p.P316P

c.948C>T

1 paper

NM_000546.6

p.P316P

c.948C>G

1 paper

NM_000546.6

p.P316A

c.946C>G

4 papers

NM_000546.6

p.S315insFs

c.945dupT

6 papers

NM_000546.6

p.P316fs

c.946_947fs

1 paper

NM_000546.6

p.P316_Q317insC

c.946_950ins3