Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S315insFs

c.945dupT

Surrounding Variants

4 papers

NM_000546.6

p.P316S

c.946C>T

1 paper

NM_000546.6

p.P316A

c.946C>G

1 paper

NM_000546.6

p.P316_Q317insC

c.946_950ins3

1 paper

NM_000546.6

p.P316insFs

c.946_947insGA

12 papers

NM_000546.6

p.P316T

c.946C>A

3 papers

NM_000546.6

p.S315delFs

c.945delA

8 papers

NM_000546.6

p.P316fs

c.946_947fs

2 papers

NM_000546.6

p.S315_P316insFs

c.945_946insC

1 paper

NM_000546.6

p.S315fs

c.943_944fs

1 paper

NM_000546.6

p.S315S

c.945T>G

1 paper

NM_000546.6

p.S314del1

c.940_941delGGA

16 papers

NM_000546.6

p.P316L

c.947C>T