Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.L308_P309del2

c.922_926del6

Surrounding Variants

18 papers

NM_000546.6

p.N310fs

c.928_929fs

2 papers

NM_000546.6

p.N310Y

c.928A>T

9 papers

NM_000546.6

p.N310D

c.928A>G

1 paper

NM_000546.6

p.N310H

c.928A>C

1 paper

NM_000546.6

p.P309insFs

c.925dupC

1 paper

NM_000546.6

p.N310_N311ins11

c.928_932ins33

8 papers

NM_000546.6

p.P309delFs

c.925delG

2 papers

NM_000546.6

p.P309P

c.927C>T

1 paper

NM_000546.6

p.P309P

c.927C>G

2 papers

NM_000546.6

p.P309fs

c.925_926fs

1 paper

NM_000546.6

p.P309_N310insFs

c.927_928insA

2 papers

NM_000546.6

p.P309P

c.927C>A