Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.P309R

c.926C>G

Surrounding Variants

7 papers

NM_000546.6

p.P309L

c.926C>T

1 paper

NM_000546.6

p.A307_P309delFs

c.921_925del5

143 papers

NM_000546.6

p.P309S

c.925C>T

2 papers

NM_000546.6

p.P309P

c.927C>T

2 papers

NM_000546.6

p.P309A

c.925C>G

1 paper

NM_000546.6

p.P309P

c.927C>G

2 papers

NM_000546.6

p.P309fs

c.925_926fs

1 paper

NM_000546.6

p.P309_N310insFs

c.927_928insA

2 papers

NM_000546.6

p.P309P

c.927C>A

2 papers

NM_000546.6

p.P309T

c.925C>A

1 paper

NM_000546.6

p.P309fs

c.925_926fs

1 paper

NM_000546.6

p.A307_L308insFs

c.920_923dup4