Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

143 papers

NM_000546.6

p.P309S

c.925C>T

Surrounding Variants

2 papers

NM_000546.6

p.P309A

c.925C>G

2 papers

NM_000546.6

p.P309T

c.925C>A

1 paper

NM_000546.6

p.P309fs

c.925_926fs

1 paper

NM_000546.6

p.A307_L308insFs

c.920_923dup4

11 papers

NM_000546.6

p.L308fs

c.922_923fs

1 paper

NM_000546.6

p.L308L

c.924G>C

3 papers

NM_000546.6

p.L308L

c.924G>A

7 papers

NM_000546.6

p.P309L

c.926C>T

4 papers

NM_000546.6

p.P309R

c.926C>G

1 paper

NM_000546.6

p.A307_P309delFs

c.921_925del5

1 paper

NM_000546.6

p.L308R

c.923T>G

4 papers

NM_000546.6

p.L308P

c.923T>C