Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.L308L

c.922C>T

Surrounding Variants

14 papers

NM_000546.6

p.L308fs

c.922_923fs

5 papers

NM_000546.6

p.L308V

c.922C>G

2 papers

NM_000546.6

p.L308M

c.922C>A

1 paper

NM_000546.6

p.A307delFs

c.921delT

1 paper

NM_000546.6

p.L308R

c.923T>G

4 papers

NM_000546.6

p.L308P

c.923T>C

3 papers

NM_000546.6

p.L308Q

c.923T>A

1 paper

NM_000546.6

p.L308delFs

c.922delG

4 papers

NM_000546.6

p.A307_L308delFs

c.921_922delGT

1 paper

NM_000546.6

p.A307A

c.921A>T

1 paper

NM_000546.6

p.A307_L308insFs

c.920_923dup4

11 papers

NM_000546.6

p.L308fs

c.922_923fs