Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A307A

c.921A>T

Surrounding Variants

14 papers

NM_000546.6

p.L308fs

c.922_923fs

20 papers

NM_000546.6

p.A307V

c.920C>T

NM_001126118.2

p.A268V

c.803C>T

4 papers

NM_000546.6

p.L308L

c.922C>T

5 papers

NM_000546.6

p.L308V

c.922C>G

5 papers

NM_000546.6

p.A307G

c.920C>G

2 papers

NM_000546.6

p.L308M

c.922C>A

2 papers

NM_000546.6

p.A307E

c.920C>A

1 paper

NM_000546.6

p.A307delFs

c.921delT

7 papers

NM_000546.6

p.A307fs

c.919_920fs

1 paper

NM_000546.6

p.L308R

c.923T>G

4 papers

NM_000546.6

p.L308P

c.923T>C

3 papers

NM_000546.6

p.L308Q

c.923T>A