Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.A307Splc

c.920-4C>T

Surrounding Variants

1 paper

NM_000546.6

p.A307Splc

c.920-4C>G

1 paper

NM_000546.6

p.A307Splc

c.920-3T>C

7 papers

NM_000546.6

p.A307Splc

c.920-5C>T

2 papers

NM_000546.6

p.A307Splc

c.920-5C>A

23 papers

NM_000546.6

p.A307Splc

c.920-2A>T

63 papers

NM_000546.6

p.A307Splc

c.920-2A>G

4 papers

NM_000546.6

p.A307Splc

c.920-2A>C

48 papers

NM_000546.6

p.A307Splc

c.920-1G>T

14 papers

NM_000546.6

p.A307Splc

c.920-1G>C

68 papers

NM_000546.6

p.A307Splc

c.920-1G>A

2 papers

NM_000546.6

p.A307Splc

c.920-8T>C

20 papers

NM_000546.6

p.A307V

c.920C>T

NM_001126118.2

p.A268V

c.803C>T