Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.A307Splc

c.920-14T>C

Surrounding Variants

2 papers

NM_000546.6

p.A307Splc

c.920-13G>C

2 papers

NM_000546.6

p.A307Splc

c.920-11C>T

2 papers

NM_000546.6

p.A307Splc

c.920-17C>A

2 papers

NM_000546.6

p.A307Splc

c.920-10T>C

1 paper

NM_000546.6

p.A307Splc

c.920-9C>T

2 papers

NM_000546.6

p.A307Splc

c.920-8T>C

7 papers

NM_000546.6

p.A307Splc

c.920-5C>T

2 papers

NM_000546.6

p.A307Splc

c.920-5C>A

2 papers

NM_000546.6

p.A307Splc

c.920-4C>T

1 paper

NM_000546.6

p.A307Splc

c.920-4C>G

1 paper

NM_000546.6

p.A307Splc

c.920-3T>C

23 papers

NM_000546.6

p.A307Splc

c.920-2A>T