Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.A307Splc

c.919+2T>A

Surrounding Variants

16 papers

NM_000546.6

p.A307Splc

c.919+2T>G

2 papers

NM_000546.6

p.A307Splc

c.919+2T>C

1 paper

NM_000546.6

p.A307delFs

c.919delC

1 paper

NM_000546.6

p.G302_R306del5

c.904_917del15

55 papers

NM_000546.6

p.A307Splc

c.919+1G>T

2 papers

NM_000546.6

p.L299_A307insFs

c.895_919dup25

14 papers

NM_000546.6

p.A307Splc

c.919+1G>C

79 papers

NM_000546.6

p.A307Splc

c.919+1G>A

1 paper

NM_000546.6

p.R306_A307delFs

c.918_919delCT

1 paper

NM_000546.6

p.P300_A307delFs

c.898_919del22

1 paper

NM_000546.6

p.E294_R306del13

c.880_917del39

2 papers

NM_000546.6

p.A307Splc

c.919+3A>G