Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R306insFs

c.917_918insA

Surrounding Variants

3 papers

NM_000546.6

p.R306L

c.917G>T

14 papers

NM_000546.6

p.R306P

c.917G>C

34 papers

NM_000546.6

p.R306Q

c.917G>A

NM_001126118.2

p.R267Q

c.800G>A

NM_001126115.2

p.R174Q

c.521G>A

4 papers

NM_000546.6

p.R306delFs

c.916delG

2 papers

NM_000546.6

p.K305_R306delFs

c.913_916del4

2 papers

NM_000546.6

p.T304_R306delFs

c.910_916del7

1 paper

NM_000546.6

p.P301_R306delFs

c.903_916del14

617 papers

NM_000546.6

p.R306*

c.916C>T

NM_001126118.2

p.R267*

c.799C>T

1 paper

NM_000546.6

p.R306G

c.916C>G

1 paper

NM_000546.6

p.K305insFs

c.915dupG

2 papers

NM_000546.6

p.R306insFs

c.916_917ins4

1 paper

NM_000546.6

p.R306insFs

c.916_917insA