Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S303R

c.909C>A

Surrounding Variants

5 papers

NM_000546.6

p.S303R

c.909C>G

1 paper

NM_000546.6

p.G302_S303insFs

c.904_908dup5

12 papers

NM_000546.6

p.S303fs

c.907_908fs

1 paper

NM_000546.6

p.S303delins

c.908_909delinsCA

1 paper

NM_000546.6

p.S303delFs

c.907_908delCT

8 papers

NM_000546.6

p.T304fs

c.910_911fs

2 papers

NM_000546.6

p.S303I

c.908G>T

6 papers

NM_000546.6

p.S303T

c.908G>C

12 papers

NM_001126115.2

p.S171N

c.512G>A

NM_000546.6

p.S303N

c.908G>A

3 papers

NM_000546.6

p.S303delFs

c.907delT

3 papers

NM_000546.6

p.T304S

c.910A>T

15 papers

NM_000546.6

p.T304A

c.910A>G