Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15 papers

NM_000546.6

p.S303fs

c.907_908fs

Surrounding Variants

3 papers

NM_000546.6

p.S303C

c.907A>T

12 papers

NM_000546.6

p.S303G

c.907A>G

4 papers

NM_000546.6

p.S303R

c.907A>C

6 papers

NM_000546.6

p.G302delFs

c.906delC

1 paper

NM_000546.6

p.G302delFs

c.905_906delCC

1 paper

NM_000546.6

p.L299_G302delFs

c.897_906del10

2 papers

NM_000546.6

p.S303I

c.908G>T

1 paper

NM_000546.6

p.G302G

c.906G>T

20 papers

NM_000546.6

p.G302fs

c.904_905fs

6 papers

NM_000546.6

p.S303T

c.908G>C

1 paper

NM_000546.6

p.G302G

c.906G>C

12 papers

NM_001126115.2

p.S171N

c.512G>A

NM_000546.6

p.S303N

c.908G>A