Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G302G

c.906G>C

Surrounding Variants

1 paper

NM_000546.6

p.G302G

c.906G>T

20 papers

NM_000546.6

p.G302fs

c.904_905fs

2 papers

NM_000546.6

p.G302G

c.906G>A

1 paper

NM_000546.6

p.L299_G302delFs

c.897_904del8

1 paper

NM_000546.6

p.K291_G302delFs

c.871_905del35

6 papers

NM_000546.6

p.G302V

c.905G>T

5 papers

NM_000546.6

p.G302A

c.905G>C

21 papers

NM_000546.6

p.G302E

c.905G>A

1 paper

NM_000546.6

p.P300_G302delFs

c.900_904del5

1 paper

NM_000546.6

p.P295_G302delFs

c.883_904del22

15 papers

NM_000546.6

p.S303fs

c.907_908fs

3 papers

NM_000546.6

p.S303C

c.907A>T