Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.G302W

c.904G>T

Surrounding Variants

1 paper

NM_000546.6

p.P301insFs

c.903dupA

17 papers

NM_000546.6

p.G302R

c.904G>C

19 papers

NM_000546.6

p.G302R

c.904G>A

18 papers

NM_000546.6

p.G302fs

c.904_905fs

4 papers

NM_000546.6

p.P301delFs

c.903delT

2 papers

NM_000546.6

p.P301del1

c.901_902delTGG

1 paper

NM_000546.6

p.P295_P301del7

c.883_902del21

6 papers

NM_000546.6

p.G302V

c.905G>T

5 papers

NM_000546.6

p.G302A

c.905G>C

21 papers

NM_000546.6

p.G302E

c.905G>A

1 paper

NM_000546.6

p.P300_G302delFs

c.900_904del5

1 paper

NM_000546.6

p.P295_G302delFs

c.883_904del22