Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

36 papers

NM_001126118.2

p.P262delFs

c.785delG

NM_001126117.2

p.P169delFs

c.506delG

NM_001276698.3

p.P142delFs

c.425delG

NM_000546.6

p.P301delFs

c.902delG

Surrounding Variants

1 paper

NM_000546.6

p.P301P

c.903A>T

5 papers

NM_000546.6

p.P301P

c.903A>G

17 papers

NM_000546.6

p.P301insFs

c.902dupC

2 papers

NM_000546.6

p.P300insFs

c.898_899dupCC

36 papers

NM_000546.6

p.P301fs

c.901_902fs

NM_001276698.3

p.P142fs

c.424_425fs

NM_001126117.2

p.P169fs

c.505_506fs

NM_001126118.2

p.P262fs

c.784_785fs

1 paper

NM_000546.6

p.P301delFs

c.901_902delGG

1 paper

NM_000546.6

p.H297_G302Fs

c.890_904delinsCGFs

1 paper

NM_000546.6

p.P295_P301delFs

c.884_902del19

9 papers

NM_000546.6

p.G302W

c.904G>T

1 paper

NM_000546.6

p.P301insFs

c.903dupA

17 papers

NM_000546.6

p.G302R

c.904G>C

19 papers

NM_000546.6

p.G302R

c.904G>A