Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L299_P300insFs

c.897_898insA

Surrounding Variants

1 paper

NM_000546.6

p.L299_P300insFs

c.897_898insT

2 papers

NM_000546.6

p.L299fs

c.895_896fs

1 paper

NM_000546.6

p.L299L

c.897G>A

1 paper

NM_000546.6

p.L299delFs

c.895_896delAG

1 paper

NM_000546.6

p.E298_L299delFs

c.893_896del4

1 paper

NM_000546.6

p.L299insFs

c.896_897insG

4 papers

NM_000546.6

p.L299R

c.896T>G

3 papers

NM_000546.6

p.L299P

c.896T>C

1 paper

NM_000546.6

p.L299Q

c.896T>A

5 papers

NM_000546.6

p.E294_H297del4

c.880_890del12

1 paper

NM_000546.6

p.P295_L299delFs

c.883_895del13

1 paper

NM_000546.6

p.K292_L299delFs

c.876_895del20