Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.H297H

c.891C>T

Surrounding Variants

7 papers

NM_000546.6

p.H297Q

c.891C>G

10 papers

NM_000546.6

p.H297fs

c.889_890fs

1 paper

NM_000546.6

p.H297insFs

c.890dupA

1 paper

NM_000546.6

p.H297insFs

c.890_891ins17

7 papers

NM_000546.6

p.H297Q

c.891C>A

2 papers

NM_000546.6

p.H297delFs

c.890delT

3 papers

NM_000546.6

p.K291_H297delFs

c.872_890del19

1 paper

NM_000546.6

p.N288_H297delFs

c.863_890del28

193 papers

NM_000546.6

p.E298*

c.892G>T

4 papers

NM_000546.6

p.E298Fs

c.892delinsTTTFs

1 paper

NM_000546.6

p.E298insFs

c.892_893insAG

1 paper

NM_000546.6

p.H297insFs

c.891dupC