Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.E294D

c.882G>C

Surrounding Variants

11 papers

NM_000546.6

p.E294D

c.882G>T

37 papers

NM_000546.6

p.E294fs

c.880_881fs

1 paper

NM_000546.6

p.E294insFs

c.881dupA

1 paper

NM_000546.6

p.E294E

c.882G>A

1 paper

NM_000546.6

p.E294delFs

c.881delT

1 paper

NM_000546.6

p.K292_E294delFs

c.874_880del7

1 paper

NM_000546.6

p.K291_E294delFs

c.872_881del10

4 papers

NM_000546.6

p.P295fs

c.883_884fs

20 papers

NM_000546.6

p.P295S

c.883C>T

1 paper

NM_000546.6

p.P295A

c.883C>G

1 paper

NM_000546.6

p.P295_H296insA

c.883_887ins3

4 papers

NM_000546.6

p.P295T

c.883C>A