Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G293_E294insA

c.877_881ins3

Surrounding Variants

27 papers

NM_000546.6

p.G293W

c.877G>T

4 papers

NM_000546.6

p.K292insFs

c.874_875insA

25 papers

NM_000546.6

p.G293R

c.877G>C

28 papers

NM_000546.6

p.G293R

c.877G>A

6 papers

NM_000546.6

p.K292delFs

c.876delT

3 papers

NM_000546.6

p.K292del1

c.874_875delTTT

1 paper

NM_000546.6

p.K291_K292del2

c.871_875del6

7 papers

NM_000546.6

p.G293V

c.878G>T

8 papers

NM_000546.6

p.G293A

c.878G>C

9 papers

NM_000546.6

p.G293E

c.878G>A

3 papers

NM_000546.6

p.K292_G293delFs

c.876_877delCT

2 papers

NM_000546.6

p.K292_G293delFs

c.874_877del4