Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R290R

c.870C>T

Surrounding Variants

1 paper

NM_000546.6

p.R290ins5

c.869_870ins15

17 papers

NM_000546.6

p.R290fs

c.868_869fs

5 papers

NM_000546.6

p.R290R

c.870C>A

1 paper

NM_000546.6

p.E287_R290delFs

c.861_868del8

1 paper

NM_000546.6

p.E286_R290delFs

c.857_869del13

1 paper

NM_000546.6

p.E286_R290delFs

c.856_869del14

22 papers

NM_001126115.2

p.R158L

c.473G>T

NM_000546.6

p.R290L

c.869G>T

8 papers

NM_000546.6

p.R290P

c.869G>C

126 papers

NM_000546.6

p.R290H

c.869G>A

NM_001126115.2

p.R158H

c.473G>A

5 papers

NM_000546.6

p.R290delFs

c.868delG

1 paper

NM_000546.6

p.L289_R290Fs

c.867_869delinsTFs

1 paper

NM_000546.6

p.L289_R290delFs

c.867_868delGG