Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.L289delFs

c.866_867delGA

Surrounding Variants

63 papers

NM_000546.6

p.R290C

c.868C>T

NM_001126115.2

p.R158C

c.472C>T

7 papers

NM_000546.6

p.R290G

c.868C>G

NM_001126115.2

p.R158G

c.472C>G

1 paper

NM_000546.6

p.L289insFs

c.866_867dupTC

1 paper

NM_000546.6

p.R290insFs

c.868_869insA

5 papers

NM_000546.6

p.R290S

c.868C>A

12 papers

NM_000546.6

p.R290fs

c.868_869fs

2 papers

NM_000546.6

p.L289_R290delins

c.867_868delinsTT

1 paper

NM_000546.6

p.N288_L289delFs

c.863_867del5

1 paper

NM_000546.6

p.E287_L289del3

c.859_866del9

22 papers

NM_001126115.2

p.R158L

c.473G>T

NM_000546.6

p.R290L

c.869G>T

8 papers

NM_000546.6

p.R290P

c.869G>C

126 papers

NM_000546.6

p.R290H

c.869G>A

NM_001126115.2

p.R158H

c.473G>A